Senior Director, Oncology Clinical Trial Operations

1 hour, 41 minutes ago
Full-time
Lead
Project and Program Management
Natera

Natera

Natera specializes in cell-free DNA testing, providing advanced genetic testing services for oncology, women's health, and organ health to help families diagnose and manage genetic diseases.

Pharmaceuticals
1K-5K
Founded 2004

Description

  • Lead the operational execution of oncology clinical trials from feasibility through study closeout.
  • Assess study concepts for feasibility, including enrollment projections, site landscape, country strategy, and operational complexity.
  • Build enrollment models and predictive analytics to support milestone delivery.
  • Lead CRO selection, scope development, governance, and ongoing operational oversight.
  • Set performance metrics and hold study teams accountable for timelines, budget, and quality standards.
  • Implement alternative sourcing models such as FSP and staff augmentation when appropriate.
  • Develop site selection and activation strategies to improve enrollment velocity.
  • Oversee laboratory readiness, performance tracking, and risk mitigation to protect data integrity.
  • Manage clinical trial budgets and track actuals against forecast.
  • Hire, train, and oversee study leaders, CRAs, and CTAs while supporting site issue resolution.

Requirements

  • Degree in a relevant scientific discipline or related field; advanced degree preferred, including MS, PharmD, MD, or PhD.
  • More than 10 years of clinical research experience, including at least 5 years in a clinical trial leadership role.
  • Significant global CRO leadership experience with governance framework and enterprise oversight model development.
  • Experience managing all aspects of clinical trials, including study design, protocol implementation, site monitoring, and recruitment site management.
  • Extensive experience overseeing oncology clinical trial programs is required.
  • Knowledge of FDA and/or EMEA regulations and GCPs governing clinical trials is required.
  • Willingness and ability to travel to clinical trial sites on short notice.
  • Proficiency in MS Word, Excel, PowerPoint, and clinical trial databases.
  • Strong interpersonal, written, and verbal communication skills, along with team-building and management ability.
  • Experience working in an entrepreneurial, fast-paced environment with hands-on leadership is preferred.

Benefits

  • Compensation range of $265,800 to $332,200 USD base salary.
  • Annual performance incentive bonus.
  • Long-term equity awards.
  • Comprehensive health benefits, including medical, dental, and vision coverage.
  • 401(k) with company match.
  • Generous paid time off and company holidays.
  • Additional wellness and work-life benefits.
  • Free testing for employees and their immediate families, plus fertility care benefits.
  • Pregnancy and baby bonding leave and commuter benefits.

Interested in this position?

Apply directly on the company website

Apply Now

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