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Senior Bioinformatics Scientist

4 months, 2 weeks ago
United States, Canada
Full-time
Senior
Data Scientist
Data Science and Analytics
AWS EC2 Python R
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Veracyte

Veracyte

Veracyte develops innovative molecular diagnostic tests that provide clinicians with critical insights to enhance cancer diagnosis and treatment, ultimately aiming to improve patient outcomes and reduce healthcare costs.

Pharmaceuticals
251-1K
Founded 2008
View All Jobs 3

Description

  • Contribute to bioinformatics strategy for MRD assay design, development, optimization, and lifecycle management under CAP/CLIA quality systems.
  • Lead study design, data analysis, performance characterization, and development decision-making.
  • Apply expertise in cancer genomics, ctDNA biology, and NGS technologies to inform assay architecture, variant detection, and error suppression approaches.
  • Design and execute analytical studies to evaluate assay accuracy, limit of detection, and reproducibility.
  • Develop, validate, and maintain scalable production-ready bioinformatics pipelines for MRD analysis, including QC, variant calling, MRD calling logic, and reporting.
  • Lead benchmarking and optimization of computational methods, including background error modeling and longitudinal MRD tracking.
  • Ensure compliance with CAP/CLIA, FDA, and IVDR standards through rigorous testing and documentation.
  • Partner with molecular biology, assay development, QA/RA, clinical, and software engineering teams to align bioinformatics with assay and regulatory requirements.
  • Contribute technical documentation, validation reports, and responses for regulatory submissions and audits.
  • Mentor junior scientists and communicate complex analytical results to technical and non-technical stakeholders, including senior leadership.

Requirements

  • Ph.D. in Bioinformatics, Computational Biology, Genomics, Biostatistics, or a closely related quantitative field, or an M.Sc. plus 3 additional years of industry experience.
  • Minimum 6 years of relevant experience in biotech, diagnostics, or regulated healthcare environments.
  • Demonstrated experience developing NGS-based assays for clinical diagnostics, including ctDNA-based MRD assays with personalized or tumor-informed approaches.
  • Strong programming skills in Python and experience building reproducible, production-grade analysis pipelines with SDLC best practices.
  • Proven experience working in design-controlled regulated environments such as CAP/CLIA LDT, IVD, or equivalent.
  • Experience developing novel bioinformatics methodologies and algorithms, including benchmarking computational methods.
  • Track record of collaborating with wet-lab scientists on iterative experiment design, execution, analysis, and interpretation.
  • Demonstrated technical and scientific ownership with the ability to work independently.
  • Preferred experience developing and deploying bioinformatics workflows in AWS, including EC2, S3, Step Functions, Batch, and Lambda.
  • Working knowledge of R and experience with relational or non-relational databases is a plus.

Benefits

  • Salary range of $170,000-$187,000 for San Diego, $177,000-$207,000 for South San Francisco, or $162,000-$178,000 for remote US candidates.
  • Eligible for additional discretionary bonuses and incentives.
  • Eligible for restricted stock units.
  • Competitive compensation and benefits.
  • Flexible work location options including onsite, hybrid, or remote US.
  • Inclusive workplace recognized as a 2024 Certified Great Place to Work in the US and Israel.

Interested in this position?

Apply directly on the company website

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