Vice President, Clinical Development

1 hour, 17 minutes ago
Full-time
Lead
Project and Program Management
Spyre Therapeutics

Spyre Therapeutics

Spyre Therapeutics is a leading company dedicated to engineering groundbreaking treatments for Inflammatory Bowel Disease (IBD), striving for unparalleled efficacy and convenience in therapy solutions.

Internet Software & Services
1-10
$266M raised

Description

  • Provide strategic and medical leadership for the clinical development of the company’s antibody portfolio in IBD.
  • Develop and refine integrated clinical development plans aligned with corporate objectives and the competitive landscape.
  • Lead the ongoing Phase 2 platform study and contribute to planning pivotal and registrational studies.
  • Oversee protocol development, medical review, safety assessment, data interpretation, and study-level decisions.
  • Provide medical and scientific নেতৃত্ব for the design, conduct, analysis, and interpretation of studies across all phases.
  • Partner with clinical operations, regulatory, biostatistics, and other functions to ensure successful trial execution.
  • Drive development decisions using emerging clinical, translational, safety, and competitive data.
  • Lead global clinical and medical strategy for regulatory interactions and submissions.
  • Oversee participant safety, benefit-risk assessments, signal detection, and risk mitigation activities.
  • Lead, mentor, and help build a high-performing clinical development team while contributing to corporate strategy.

Requirements

  • MD or equivalent medical degree is required.
  • 7+ years of clinical development experience in the pharmaceutical or biotech industry.
  • Substantial leadership experience in immunology, inflammation, or gastroenterology.
  • Training and/or experience in gastroenterology or immunology and inflammation is strongly preferred.
  • Demonstrated success leading mid- and late-stage clinical development programs.
  • Experience developing antibody therapeutics.
  • Experience leading complex adaptive, umbrella, basket, or platform trials is highly desirable.
  • Deep expertise in inflammatory bowel disease or other immune-mediated inflammatory disorders is strongly preferred.
  • Significant experience with global regulatory interactions and submissions, including INDs, CTAs, and briefing packages.
  • Strong understanding of clinical trial design, biostatistics, translational medicine, drug development, and global regulatory requirements.

Benefits

  • Market-competitive compensation and benefits package, including base salary, performance bonus, and equity grant opportunities.
  • Health, welfare, and retirement benefits.
  • Unlimited PTO.
  • Two one-week company-wide shutdowns each year.
  • Professional development opportunities.
  • Remote working environment with frequent in-person meetings.
  • Expected salary range of $366,000 to $398,000.

Interested in this position?

Apply directly on the company website

Apply Now

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