Senior Director, Clinical Development

1 hour, 1 minute ago
Full-time
Lead
Project and Program Management
Loyal

Loyal

Loyal is a clinical-stage biotechnology company based in San Francisco, California, founded in 2020. The company is dedicated to developing prescription drugs aimed at extending the healthy lifespan and improving the quality of life for dogs. Loyal focuses on preventive care by addressing age-associated diseases and metabolic dysfunction in dogs, particularly large breeds. The company is led by CEO Celine Halioua and has raised over $116.81 million in funding, with ongoing efforts to secure FDA approvals through its Center for Veterinary Medicine. Loyal's drug development pipeline includes three main products targeting longevity and healthy aging in dogs. LOY-002 is designed for senior dogs and aims to correct metabolic dysfunction, while LOY-001 and LOY-003 focus on correcting IGF-1 and growth hormone overexpression in large dogs. The company is conducting a nationwide clinical study called STAY, enrolling 1,300 senior dogs across 70 veterinary clinics. Loyal emphasizes partnerships with veterinary professionals for the administration of its products and conducts research involving DNA sequencing from canine saliva samples.

research
201-500
Founded 2020
$238M raised

Description

  • Own the clinical development strategy for the veterinary drug portfolio, including target product profiles, pivotal pathway planning, and key endpoints.
  • Build and manage development timelines and communicate program strategy across internal teams.
  • Design companion animal clinical trials, including pilot, field safety, and pivotal effectiveness studies.
  • Develop protocols, investigator brochures, SAP inputs, and other study documents for veterinary practice settings.
  • Partner with statisticians on study design, randomization, interim analyses, and data quality plans.
  • Work with Clinical Operations to execute studies with GCP compliance and provide medical oversight during the in-life phase.
  • Provide medical and scientific oversight for eligibility decisions, case reviews, AE/SAE reporting, protocol deviations, and clinical data interpretation.
  • Lead clinical regulatory interactions with FDA-CVM, including pre-submission meetings, technical section responses, protocol reviews, and evidence summaries.
  • Collaborate with R&D, Regulatory, Veterinary Affairs, Clinical Operations, and Commercial teams to align studies with development and approval goals.
  • Lead clinical data review, analyses, messaging strategy, and author study reports, abstracts, presentations, and clinical narratives.
  • Build, mentor, and manage a growing clinical development team.

Requirements

  • DVM or equivalent degree.
  • 10-12+ years of experience in animal health clinical development.
  • Demonstrated experience designing and leading clinical trials, including protocol authorship, data review, and cross-functional collaboration.
  • Prior oversight of safety evaluation, study conduct, and interpretation of clinical endpoints.
  • Strong understanding of evidence requirements for regulatory approval.
  • Ability to lead in a fast-paced, high-accountability biotech environment.
  • Direct experience with FDA-CVM VICH guidelines.
  • Experience in companion animal medicine; experience in aging, longevity, or quality-of-life endpoints is preferred.
  • Background working with veterinary clinics, practice networks, or decentralized trial models.

Benefits

  • Salary range of $230,000 to $270,000.
  • Full-coverage medical, dental, and vision insurance for employees and dependents.
  • $1,000 home office equipment stipend.
  • $1,200 annual learning budget for books, courses, and similar development expenses.
  • $250 monthly wellness budget for gym, cleaners, spa, food, and similar expenses.
  • Unlimited vacation, paid holidays, and all 3-day weekends turned into 4-day weekends.
  • Paw-ternity leave with a day off when you adopt a dog.
  • Company equity options grant for new hires.

Interested in this position?

Apply directly on the company website

Apply Now

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