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Lead Bioinformatician (cfDNA Algorithms and Pipelines)

3 weeks, 6 days ago
United States
Full-time
Senior
Data Scientist
Data Science and Analytics
Prototyping Python
Apply Now
Natera

Natera

Natera specializes in cell-free DNA testing, providing advanced genetic testing services for oncology, women's health, and organ health to help families diagnose and manage genetic diseases.

Pharmaceuticals
1K-5K
Founded 2004
View All Jobs 32

Description

  • Provide genomics algorithm guidance for the expanded panel roadmap and help evaluate which genes and assay edge cases to include.
  • Define the computational strategy for new targeted and special-purpose variant callers.
  • Prototype, benchmark, and help productionize new bioinformatics methods.
  • Investigate complex production issues and distinguish biological causes from analytical or pipeline-related causes.
  • Turn investigation findings into durable rules and design changes that reduce repeat work.
  • Serve as a bioinformatics liaison with Variant Management, Reporting, and Laboratory Operations on data quality, variant representation, and system integration.
  • Provide scientific rationale for method readiness and deployment decisions.
  • Help define correct use of AI-assisted scientific investigation and human review boundaries.
  • Contribute to product roadmaps and deployment-readiness criteria for analysis methods.

Requirements

  • Degree in Bioinformatics, Computational Biology, Human Genetics, or a related field; equivalent work experience is accepted in place of an M.S. or Ph.D.
  • 4+ years analyzing short-read sequencing data for screening or diagnostic applications, preferably in a regulated, accredited, or production-adjacent setting.
  • Experience contributing to the bioinformatics workflows behind a sequencing assay or panel.
  • Experience resolving complex investigations across biological, analytical, and systems-level causes.
  • Experience developing, validating, or benchmarking bioinformatics methods such as SNVs, CNVs, and SVs, especially in difficult regions.
  • Proficiency in Python with experience prototyping bioinformatics tools or callers.
  • Depth in human genetics, including variant spectrum, population frequency, and tradeoffs in assay accuracy.
  • Familiarity with short-read mapping limitations, including homologous sequence, pseudogenes, repeats, low-complexity regions, and copy-number-heavy regions.
  • Experience contributing to study designs or performance criteria for a bioinformatics analysis method.
  • Preferred: direct non-invasive prenatal, reproductive, or carrier screening experience.
  • Preferred: experience with cfDNA or other low-abundance target applications.
  • Preferred: experience developing algorithms for short-read and long-read platforms such as Illumina, ONT, or PacBio.
  • Preferred: cross-functional credibility with genetic counseling, variant management, reporting, and production-adjacent groups.
  • Preferred: experience in an accredited or high-complexity laboratory, or with production support and escalation processes.

Benefits

  • Remote USA role.
  • Base salary range of $130,900 to $163,600 USD.
  • Comprehensive medical, dental, vision, life, and disability coverage for eligible employees and dependents.
  • Free testing for employees and their immediate families.
  • Fertility care benefits.
  • Pregnancy and baby bonding leave.
  • 401(k) benefits.
  • Commuter benefits and a generous employee referral program.

Interested in this position?

Apply directly on the company website

Apply Now

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