Director, Portfolio Strategy - Global Initiatives

7 hours, 12 minutes ago
Full-time
Senior
Project and Program Management
Flagship Pioneering

Flagship Pioneering

Flagship Pioneering is a biotechnology firm that invents and develops innovative life science platforms and companies aimed at transforming human health and promoting sustainability.

Biotechnology
251-1K
Founded 1999

Description

  • Shape portfolio strategy and investment decisions across the BioMedicines pipeline from preclinical inception through development.
  • Build and advance new R&D programs, including development paths, milestones, resourcing plans, and decision points.
  • Develop integrated investment cases that synthesize scientific rationale, development feasibility, execution risk, and value creation.
  • Lead portfolio reviews, scenario planning, and trade-off analyses across indication selection, timing, resourcing, and probability-adjusted value.
  • Evaluate internal and external opportunities through scientific, technical, strategic, and operational diligence.
  • Identify portfolio risks, gaps, and opportunities and recommend actions such as acceleration, de-prioritization, partnering, or termination.
  • Translate complex scientific, clinical, and financial information into concise executive-level insights and decision materials.
  • Collaborate across R&D, Clinical Development, Regulatory, CMC, Finance, Commercial, Partnering, and internal venture teams.
  • Work directly with senior scientific and executive leaders to create and execute new programs.
  • Support governance and decision-making forums that enable speed, clarity, and accountability.
  • Contribute to special strategic initiatives with Flagship Pioneering leadership.

Requirements

  • PhD or MD in life sciences or a related field.
  • 5+ years of experience in management consulting, biotech venture creation or investing, biopharma portfolio strategy, or a related role.
  • Strong understanding of biopharma R&D, clinical development, and regulatory pathways.
  • Experience working across multiple programs and stages of drug development.
  • Demonstrated experience with portfolio construction, scenario planning, and risk-adjusted decision-making.
  • Exceptional ability to synthesize complex data and communicate clearly with executives.
  • Proven ability to influence senior scientific and business leaders without formal authority.
  • Experience within the Flagship ecosystem is strongly valued.
  • Ability to operate effectively in a fast-paced, ambiguity-rich environment.
  • Willingness to work hands-on and own analyses, materials, and decision support end to end.

Benefits

  • Salary range of $172,000 - $236,500.
  • Healthcare coverage.
  • Annual incentive program.
  • Retirement benefits.
  • Broad range of additional benefits.

Interested in this position?

Apply directly on the company website

Apply Now

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