Translational Biology Expert

1 hour, 48 minutes ago
Contract
Senior
Data Science and Analytics
Weekday

Weekday

Weekday helps companies hire engineers who are vouched by other software engineers, enabling passive income for engineers. They offer services like drafting outreach messages, shortlisting candidates, and conducting reference checks. Backed by Y Combin...

Construction & Engineering
11-50
Founded 2020

Description

  • Design and execute in vivo and in vitro studies that connect molecular mechanisms to disease-relevant outcomes.
  • Select preclinical models with strong rationale for human translatability.
  • Develop biomarker strategies from target engagement through clinical response.
  • Evaluate formulation and delivery strategies for optimal tissue targeting.
  • Troubleshoot inconclusive or negative results and recommend next steps.
  • Build exposure-response relationships and assess whether preclinical evidence supports target engagement and therapeutic activity.
  • Refine mechanistic hypotheses, design follow-up experiments, and evaluate early safety signals and immunogenicity risks.
  • Support portfolio decisions, including advancement, pivot, or termination, based on data quality and risk.
  • Define first-in-human starting doses, dose escalation strategies, endpoints, interim analyses, and safety monitoring plans.
  • Conduct exposure-response analysis, dose optimization, population PK/PD modeling, and longitudinal treatment-response modeling.
  • Design statistical analysis plans, sample size calculations, multiplicity adjustments, subgroup analyses, and adaptive trial designs.

Requirements

  • PhD, MD, or PharmD in Pharmacology, Pharmaceutical Sciences, Biostatistics, Quantitative Biology, or a related field.
  • 5+ years of industry experience in pharma, biotech, or CRO environments.
  • Direct experience supporting programs from late preclinical stages through IND or early clinical development.
  • Strong ability to independently evaluate complex datasets and provide clear, actionable recommendations.
  • Excellent communication skills for both technical and non-technical stakeholders.
  • Based in the United States or the United Kingdom.
  • Experience with PK/PD modeling, biostatistics, or clinical modeling is expected.
  • Experience with non-confidential, publicly available information only is required for this engagement.
  • Candidates requiring H1-B or STEM OPT sponsorship are not eligible.

Benefits

  • Compensation of $110-$135 per hour.
  • Fully remote work with flexible working hours.
  • Independent contractor engagement.
  • Weekly payments processed via Stripe or Wise.
  • Project duration may vary based on performance and business needs.

Interested in this position?

Apply directly on the company website

Apply Now

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