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Senior Staff Biostatistician

1 month, 2 weeks ago
United States
Full-time
Senior
Data Scientist
Data Science and Analytics
Python R Statistics
Apply Now
N-Power Medicine

N-Power Medicine

N-Power Medicine accelerates drug development by creating a research-ready network that integrates standard of care patients and diverse populations into clinical trials, facilitating informed decision-making for phase II to phase III studies in oncology.

Biotechnology
11-50
Founded 2021
View All Jobs 6

Description

  • Build expert capabilities in prospective external control arms and hybrid controls that combine retrospective and prospective real-world data with single-arm and randomized controlled trials.
  • Develop statistical methodologies to address observed and unobserved selection, confounding, and measurement bias in external control and hybrid control studies.
  • Guide and mentor internal teams on novel methodologies, best statistical practices, innovative clinical trial designs, statistical inference, and results reporting.
  • Collaborate with Clinical Science and Commercial teams on clinical study plans, protocols, regulatory strategy, target product profiles, and integrated evidence plans.
  • Work with Data and Technology partners to define data requirements and data collection processes for next-generation external control arms.
  • Lead or support study scoping, including sample size calculations and identification of data needs.
  • Lead or support study design, bias mitigation approaches, protocol development, and statistical analysis plan development.
  • Execute analysis plans and develop adjacent algorithms and scalable tools to support study delivery.
  • Communicate novel methodology and co-author study results in peer-reviewed publications, presentations, and health authority reports.
  • Participate in cross-functional discussions on data strategy, platform strategy, and workflow development, and help improve tools, pipelines, scalability, and reproducibility.

Requirements

  • 5+ years of industry or research experience, or equivalent experience.
  • PhD in Statistics, Biostatistics, or a related field.
  • Expert knowledge of theoretical and applied statistics, including inferential methods for time-to-event analysis, survival analysis, and causal inference methods.
  • Experience designing and analyzing externally controlled studies and hybrid controls, including propensity score methods, endpoint measurement bias correction methods, and Bayesian and frequentist external patient borrowing methods.
  • Fundamental understanding of clinical and efficacy endpoints used in oncology development.
  • Experience collaborating with clinical, biomarker, and imaging scientists on oncology drug development.
  • Extensive programming experience in R and/or Python.
  • Strong communication, collaboration, and statistical consulting skills.
  • Excellent project management skills, including the ability to manage scope and delegate to staff, contractors, and external vendors.
  • Ability to work in a fast-paced startup environment, with an entrepreneurial, credible, and creative approach; applicants must be authorized to work in the U.S. full time and the company will not sponsor work visas.
  • Travel may be required from time to time.

Benefits

  • Salary range of $186,000 to $259,000.
  • Equity at hire.
  • Discretionary annual bonus based on company performance.
  • Company benefits package.
  • Balanced and flexible work environment.
  • 401(k) plan.
  • Competitive industry benefits and other company perks.

Interested in this position?

Apply directly on the company website

Apply Now

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